The ABCs of ATP-sensitive Potassium Channels: More Pieces of the Puzzle

Curr Opin Cell Biol. 1997 Aug;9(4):553-9. doi: 10.1016/s0955-0674(97)80033-6.

Abstract

ATP-sensitive potassium channels, KATP channels are critical for the normal regulation of insulin secretion. The cloning of cDNAs encoding the subunits of these channels shows that they are a novel combination of an ATP-binding protein and a small inward rectifier. Loss of pancreatic beta-cell KATP channels has been shown to cause familial hyperinsulinism.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.
  • Review

MeSH terms

  • ATP-Binding Cassette Transporters / physiology*
  • Adenosine Triphosphate / metabolism*
  • Animals
  • Humans
  • Models, Biological
  • Models, Structural
  • Molecular Sequence Data
  • Potassium Channels / chemistry
  • Potassium Channels / genetics
  • Potassium Channels / physiology*
  • Potassium Channels, Inwardly Rectifying*
  • Protein Structure, Secondary
  • Receptors, Drug / chemistry
  • Receptors, Drug / genetics
  • Receptors, Drug / physiology
  • Sulfonylurea Receptors

Substances

  • ATP-Binding Cassette Transporters
  • Potassium Channels
  • Potassium Channels, Inwardly Rectifying
  • Receptors, Drug
  • Sulfonylurea Receptors
  • Adenosine Triphosphate

Associated data

  • GENBANK/U90583