Regulation of aquaporin-2 water channel trafficking by vasopressin

Curr Opin Cell Biol. 1997 Aug;9(4):560-4. doi: 10.1016/s0955-0674(97)80034-8.

Abstract

Vasopressin regulates water excretion from the kidney by increasing the osmotic water permeability of the renal collecting duct. The aquaporin-2 water channel has been demonstrated to be the target for this action of vasopressin. Recent studies have demonstrated that vasopressin, acting through cyclic AMP, triggers fusion of aquaporin-2-bearing vesicles with the apical plasma membrane of the collecting duct principal cells. The vesicle-targeting proteins synaptobrevin-2 and syntaxin-4 are proposed to play roles in this process.

Publication types

  • Review

MeSH terms

  • Animals
  • Aquaporin 2
  • Aquaporin 6
  • Aquaporins*
  • Cell Membrane / physiology
  • Cyclic AMP / physiology
  • Ion Channels / chemistry
  • Ion Channels / physiology*
  • Kidney Tubules, Collecting / physiology*
  • Membrane Fusion
  • Membrane Proteins / physiology
  • Models, Biological
  • Models, Structural
  • Qa-SNARE Proteins
  • R-SNARE Proteins
  • SNARE Proteins
  • Signal Transduction
  • Vasopressins / physiology*
  • Vesicular Transport Proteins*
  • Water-Electrolyte Balance

Substances

  • Aquaporin 2
  • Aquaporin 6
  • Aquaporins
  • Ion Channels
  • Membrane Proteins
  • Qa-SNARE Proteins
  • R-SNARE Proteins
  • SNARE Proteins
  • Vesicular Transport Proteins
  • Vasopressins
  • Cyclic AMP