Abstract
Several lines of evidence indicate that enzymes that modify membrane lipids function in the regulation of constitutive membrane traffic. Recent evidence suggests that specific phosphatidylinositides may regulate the activity of proteins with diverse functions in membrane transport, such as dynamin, the clathrin-associated AP-2 complex, and proteins that stimulate guanine nucleotide exchange on ADP-ribosylation factors (ARFs). ARF proteins activate a phospholipase D that produces phosphatidic acid from phosphatidylcholine, and this may be essential for the formation of certain types of transport vesicles or may be constitutive vesicular transport to signal transduction pathways.
Publication types
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Research Support, Non-U.S. Gov't
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Research Support, U.S. Gov't, P.H.S.
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Review
MeSH terms
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ADP-Ribosylation Factors
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Animals
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Cell Membrane / physiology*
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Clathrin / physiology
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DNA-Binding Proteins / metabolism
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GTP-Binding Proteins / metabolism
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Guanine Nucleotides / metabolism
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Intracellular Membranes / physiology*
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Membrane Lipids / physiology*
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Membrane Proteins / physiology*
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Models, Biological
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Phosphatidylinositols / metabolism
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Phospholipase D / metabolism
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Signal Transduction*
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Transcription Factor AP-2
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Transcription Factors / metabolism
Substances
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Clathrin
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DNA-Binding Proteins
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Guanine Nucleotides
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Membrane Lipids
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Membrane Proteins
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Phosphatidylinositols
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Transcription Factor AP-2
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Transcription Factors
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Phospholipase D
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GTP-Binding Proteins
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ADP-Ribosylation Factors