Family of neutral and acidic amino acid transporters: molecular biology, physiology and medical implications

Curr Opin Cell Biol. 1997 Aug;9(4):565-72. doi: 10.1016/s0955-0674(97)80035-x.


Glutamate transporters and structurally related neutral amino acid transporters constitute a distinct family of Na(+)-dependent transporters. The different transporters of this family share similar structural traits, and exhibit different yet comparable functions. Significant recent advances in our understanding of the structure and function of these transporters include: a new twist in our knowledge of ion-coupling stoichiometry; the knockout of glutamate transporters, which reveals a major role for glial glutamate transporters; and new insights into the regulation of glutamate transporter expression.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • ATP-Binding Cassette Transporters / genetics
  • ATP-Binding Cassette Transporters / metabolism*
  • Alzheimer Disease / metabolism
  • Amino Acid Transport System X-AG
  • Amino Acids / metabolism*
  • Amyotrophic Lateral Sclerosis / metabolism
  • Animals
  • Biological Transport
  • Brain / metabolism
  • Carrier Proteins / metabolism*
  • Humans
  • Nerve Degeneration
  • Neurons / metabolism
  • Spinal Cord / metabolism
  • Substrate Specificity


  • ATP-Binding Cassette Transporters
  • Amino Acid Transport System X-AG
  • Amino Acids
  • Carrier Proteins