Background/aims: In view of previous studies showing gastrin's trophic effects on tumor growth, the authors decided to investigate the relationship between fasting serum gastrin levels and the presence of colorectal carcinoma.
Methodology: Fifty-eight patients were studied: 19 controls who were blood bank donors, 19 patients with colorectal neoplasms, Dukes' Stage B or C, and 20 patients with advanced colorectal neoplasms (Dukes' Stage D). Pre-surgical and post-surgical serum gastrin levels were compared in patients with colorectal neoplasms (Dukes' Stage B or C).
Results: The mean serum gastrin level was 32.3 pg/ml for the control group, 52.1 pg/ml for the second group and 49.5 pg/ml for the third group. There were no differences between patients before and after surgery.
Conclusion: These results do not confirm the hypothesis that gastrin levels are elevated in colorectal cancer patients.