Proliferative potentials of glioma cells and vascular components determined with monoclonal antibody MIB-1

J Exp Clin Cancer Res. 1997 Jun;16(2):153-7.

Abstract

Proliferative activity in 78 glioma specimens was assessed immunohistochemically by determining proliferating index of tumor cells (PTC-PI) and endothelial cells (PEC-PI) using the MIB-1 monoclonal antibody. The PTC-PI of anaplastic astrocytoma (9.0 +/- 5.8: mean + standard deviation) was significantly higher than that of astrocytoma (1.2 +/- 0.4, < 0.01), and lower than that of glioblastoma multiforme (12.0 +/- 5.6, < 0.05). We then compared PTC-PI values with the prognosis of patients with malignant glioma (both glioblastoma and anaplastic astrocytoma). Kaplan-Meier survival rate analysis demonstrated higher survival rates in patients with less than 8.0% of PTC-PI at 5 and 10 years (p < 0.05). These results suggested PTC-PI provides useful information which may allow better assessment of the biological behaviour and clinical prognosis of glioma, in addition to histological grading. While the average PEC-PI value (3.3) was lower than that of PTC-PI (7.0), there was a significantly close relationship between them (p < 0.01), fostering the developments novel therapies directed towards suppression of microvascular regeneration.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Antibodies, Monoclonal*
  • Astrocytoma / blood supply
  • Astrocytoma / pathology
  • Brain Neoplasms / blood supply*
  • Brain Neoplasms / pathology*
  • Cell Division / physiology
  • Endothelium, Vascular / cytology*
  • Glioblastoma / blood supply
  • Glioblastoma / pathology
  • Glioma / blood supply*
  • Glioma / pathology*
  • Humans
  • Immunohistochemistry
  • Neovascularization, Pathologic / pathology*
  • Prognosis

Substances

  • Antibodies, Monoclonal