Voltage-activated intracellular calcium transients in thalamic relay cells and interneurons

Neuroreport. 1997 Jul 28;8(11):2411-8. doi: 10.1097/00001756-199707280-00001.


The dynamics of intracellular calcium concentration ([Ca2+]i) following activation of low voltage-activated (LVA) and high voltage-activated (HVA) Ca2+ currents were studied in identified relay neurons and interneurons of the rat dorsal lateral geniculate nucleus (LGNd) in situ using Ca2+ imaging and patch-clamp techniques. In relay neurons, [Ca2+]i transients associated with the LVA Ca2+ current showed a fairly homogeneous somatodendritic distribution, whereas HVA transients significantly decreased to 65% of the somatic value at 60 microns dendritic distance. In interneurons, LVA transients significantly increased to 239% of the somatic value at 60 microns dendritic distance, whereas HVA transients were not significantly different in the soma and dendrites. These results indicate differences in [Ca2+]i dynamics, which may reflect a heterogeneous distribution of Ca2+ channels contributing to subcellular compartmentation in the two types of thalamic neurons.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Calcium / metabolism*
  • Calcium Channels / physiology*
  • Dendrites / physiology
  • Evoked Potentials
  • Geniculate Bodies / physiology*
  • In Vitro Techniques
  • Interneurons / physiology*
  • Membrane Potentials
  • Microscopy, Video
  • Neurons / physiology*
  • Patch-Clamp Techniques
  • Rats
  • Rats, Wistar


  • Calcium Channels
  • Calcium