Natural Functions of Bacterial Multidrug Transporters

Trends Microbiol. 1997 Aug;5(8):309-13. doi: 10.1016/S0966-842X(97)01064-0.

Abstract

Bacteria express several multidrug transporters that recognize structurally dissimilar toxic molecules and expel them from cells. These transporters may have evolved to protect bacteria from diverse environmental toxins or to transport specific physiological compounds with the ability to expel drugs being only a fortuitous side effect.

Publication types

  • Comparative Study
  • Research Support, U.S. Gov't, P.H.S.
  • Review

MeSH terms

  • ATP Binding Cassette Transporter, Subfamily B, Member 1 / genetics
  • ATP Binding Cassette Transporter, Subfamily B, Member 1 / physiology*
  • Bacteria / drug effects
  • Bacteria / genetics
  • Bacterial Physiological Phenomena*
  • Biological Evolution
  • Drug Resistance, Multiple / genetics
  • Drug Resistance, Multiple / physiology
  • Models, Biological

Substances

  • ATP Binding Cassette Transporter, Subfamily B, Member 1