NGF antibodies impair long-term depression at the mossy fibre-CA3 synapse in the developing hippocampus

Brain Res Dev Brain Res. 1997 Jul 18;101(1-2):295-7. doi: 10.1016/s0165-3806(97)00082-5.

Abstract

Nerve growth factor (NGF) and other neurotrophins are proteins involved in neuronal survival and differentiation. Much experimental evidence is now drawing attention into a role of neurotrophins in activity-dependent synaptic plasticity processes. We now show that slices from rats chronically deprived of NGF, by intraventricular injection of alpha D11 hybridoma cells, which produce monoclonal antibodies against NGF, display a reduced probability of induction of long-term depression at the mossy fibre-CA3 synapse.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Antibodies, Monoclonal / biosynthesis
  • Antibodies, Monoclonal / physiology
  • Cell Transplantation / physiology
  • Evoked Potentials / drug effects
  • Hippocampus / cytology
  • Hippocampus / drug effects*
  • Hybridomas / immunology
  • Hybridomas / metabolism
  • In Vitro Techniques
  • Multiple Myeloma / immunology
  • Neoplasm Transplantation / physiology
  • Nerve Fibers / drug effects*
  • Nerve Growth Factors / immunology
  • Nerve Growth Factors / physiology*
  • Neuronal Plasticity / drug effects*
  • Rats
  • Rats, Wistar
  • Synapses / drug effects*

Substances

  • Antibodies, Monoclonal
  • Nerve Growth Factors