Abstract
Nerve growth factor (NGF) and other neurotrophins are proteins involved in neuronal survival and differentiation. Much experimental evidence is now drawing attention into a role of neurotrophins in activity-dependent synaptic plasticity processes. We now show that slices from rats chronically deprived of NGF, by intraventricular injection of alpha D11 hybridoma cells, which produce monoclonal antibodies against NGF, display a reduced probability of induction of long-term depression at the mossy fibre-CA3 synapse.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Animals
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Antibodies, Monoclonal / biosynthesis
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Antibodies, Monoclonal / physiology
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Cell Transplantation / physiology
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Evoked Potentials / drug effects
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Hippocampus / cytology
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Hippocampus / drug effects*
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Hybridomas / immunology
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Hybridomas / metabolism
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In Vitro Techniques
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Multiple Myeloma / immunology
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Neoplasm Transplantation / physiology
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Nerve Fibers / drug effects*
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Nerve Growth Factors / immunology
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Nerve Growth Factors / physiology*
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Neuronal Plasticity / drug effects*
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Rats
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Rats, Wistar
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Synapses / drug effects*
Substances
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Antibodies, Monoclonal
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Nerve Growth Factors