Serotonin facilitates synaptic plasticity in kitten visual cortex: an in vitro study

Brain Res Dev Brain Res. 1997 Jul 18;101(1-2):299-304. doi: 10.1016/s0165-3806(97)00083-7.

Abstract

We have addressed the role of serotonin-2C (5-HT2C) receptors in the development and maintenance of synaptic plasticity in the kitten visual cortex. In visual cortical slices, taken from 40- to 80-day-old kittens, bath application of serotonin markedly facilitated the induction of both long-term depression (LTD) and long-term potentiation (LTP). Field potential responses to white matter stimulation were recorded from layer IV after a regime of low frequency stimulation (LFS; 1 Hz, 15 min), which reliably induced LTP or LTD in younger kittens (less than 30 days of age). At 40-80 days, this protocol almost never induced LTD or LTP in layer IV. However, in 50% of the visual cortical slices studied in 40-80-day-old kittens, LTD or LTP was induced, if serotonin (1 or 10 microM) was co-applied with LFS. No such serotonin facilitation of long-term plasticity was ever detected in > 120-day-old animals, indicating that serotonin facilitates synaptic plasticity within a defined period of visual cortical development. Serotonergic 5-HT2C receptors are likely to contribute to the synaptic plasticity observed in layer IV, since mesulergine, an antagonist of the 5-HT2C receptor, completely blocked synaptic modifications induced by the combination of low frequency stimulation and serotonin application.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Aging / physiology
  • Animals
  • Cats
  • Electric Stimulation
  • In Vitro Techniques
  • Long-Term Potentiation / drug effects
  • Long-Term Potentiation / physiology
  • Neuronal Plasticity / drug effects
  • Neuronal Plasticity / physiology*
  • Neurotransmitter Agents / physiology
  • Receptors, Serotonin / drug effects
  • Receptors, Serotonin / physiology
  • Serotonin / pharmacology
  • Serotonin / physiology*
  • Visual Cortex / drug effects
  • Visual Cortex / physiology*

Substances

  • Neurotransmitter Agents
  • Receptors, Serotonin
  • Serotonin