Endothelin in ischemic acute renal failure

Curr Opin Nephrol Hypertens. 1997 Jul;6(4):394-400. doi: 10.1097/00041552-199707000-00015.


The endothelin peptides comprise a family of potent and long-lasting vascoconstrictors, to which the renal microcirculation is particularly susceptible. Increased renal endothelin expression is observed after a variety of injurious stimuli, including ischemia, and persists for days after resolution of the initial injury. Autoinduction of its own production is likely to be a central mechanism underlying endothelin's prolonged effects. Furthermore, antagonizing endothelin reveals its role in maintaining the postischemic glomerular dysfunction that typifies ischemic acute renal failure.

Publication types

  • Review

MeSH terms

  • Acute Kidney Injury / etiology
  • Acute Kidney Injury / physiopathology*
  • Animals
  • Endothelins / antagonists & inhibitors
  • Endothelins / physiology*
  • Humans
  • Ischemia / physiopathology*
  • Kidney / blood supply*
  • Kidney / injuries
  • Kidney / physiopathology*
  • Receptors, Endothelin / physiology


  • Endothelins
  • Receptors, Endothelin