Epithelial differentiation in Drosophila

Bioessays. 1997 Aug;19(8):673-82. doi: 10.1002/bies.950190807.


Our understanding of epithelial development in Drosophila has been greatly improved in recent years. Two key regulators of epithelial polarity, Crumbs and DE-cadherin, have been studied at the genetic and molecular levels and a number of additional genes are being analyzed that contribute to the differentiation of epithelial cell structure. Epithelial architecture has a profound influence on morphogenetic movements, patterning and cell-type determination. The combination of embryological and genetic/molecular tools in Drosophila will help us to elucidate the complex events that determine epithelial cell structure and how they relate to morphogenesis and other developmental processes.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Blastoderm / cytology
  • Blastoderm / physiology
  • Cadherins / physiology
  • Cell Communication
  • Cell Differentiation
  • Cell Polarity
  • Digestive System / embryology
  • Digestive System / growth & development
  • Drosophila / embryology
  • Drosophila / genetics
  • Drosophila / growth & development*
  • Epithelial Cells
  • Epithelium / growth & development
  • Membrane Proteins / physiology
  • Models, Biological
  • Morphogenesis


  • Cadherins
  • Membrane Proteins