The expression of interleukin-8 receptor in untreated and treated psoriasis

Arch Dermatol Res. 1997 Jul;289(8):440-3. doi: 10.1007/s004030050218.

Abstract

The expression of IL-8 in psoriasis has been clearly shown with the use of immunocytochemical, RT-PCR and in situ hybridization methods. The presence of its ligand, the IL-8 receptor, has been demonstrated by the RT-PCR technique. We report here a study of the expression of both IL-8 type A and B receptors by immunohistochemical techniques, using one polyclonal and four monoclonal antibodies. By this technique, we found that the neutrophilic granulocytes express the IL-8 type A receptor, whereas the IL-8 type B receptor was present on the keratinocytes. The type B receptor on the keratinocytes was localized in the suprabasal layers of the epidermis. Following therapy, the expression of the IL-8 type B receptor on the keratinocytes was reduced. This could suggest that IL-8 in psoriasis is involved in the disturbed differentiation rather than in proliferation, probably via an autocrine loop.

MeSH terms

  • Animals
  • Antigens, CD / analysis*
  • Humans
  • Immunohistochemistry
  • Mice
  • Psoriasis / metabolism*
  • Psoriasis / therapy
  • Rabbits
  • Receptors, Interleukin / analysis*
  • Receptors, Interleukin-8A
  • Skin / chemistry

Substances

  • Antigens, CD
  • Receptors, Interleukin
  • Receptors, Interleukin-8A