Modeling transmembrane helical oligomers

Curr Opin Struct Biol. 1997 Aug;7(4):486-94. doi: 10.1016/s0959-440x(97)80111-x.

Abstract

Recently, methods for the analysis and design of water-soluble, oligomeric bundles of alpha helices, including coiled coils, have reached a high level of sophistication. These same methods may now be applied to transmembrane helical bundles. Studies of the transmembrane domains of glycophorin, phospholamban, and the M2 protein from influenza A virus exemplify this general approach.

Publication types

  • Review

MeSH terms

  • Calcium-Binding Proteins / chemistry
  • Computer Simulation
  • Glycophorins / chemistry
  • Influenza A virus / chemistry
  • Membrane Proteins / chemistry*
  • Models, Molecular*
  • Protein Conformation
  • Viral Matrix Proteins / chemistry

Substances

  • Calcium-Binding Proteins
  • Glycophorins
  • M-protein, influenza virus
  • M2 protein, Influenza A virus
  • Membrane Proteins
  • Viral Matrix Proteins
  • phospholamban