Coenzyme Q10 levels correlate with the activities of complexes I and II/III in mitochondria from parkinsonian and nonparkinsonian subjects

Ann Neurol. 1997 Aug;42(2):261-4. doi: 10.1002/ana.410420221.


The activities of complex I and complex II/III in platelet mitochondria are reduced in patients with early, untreated Parkinson's disease. Coenzyme Q10 is the electron acceptor for complex I and complex II. We found that the level of coenzyme Q10 was significantly lower in mitochondria from parkinsonian patients than in mitochondria from age- and sex-matched control subjects and that the levels of coenzyme Q10 and the activities of complex I and complex II/III were significantly correlated.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Blood Platelets / enzymology
  • Coenzymes
  • Electron Transport Complex II
  • Electron Transport Complex III / metabolism*
  • Female
  • Humans
  • Male
  • Mitochondria / enzymology*
  • Multienzyme Complexes / metabolism*
  • NAD(P)H Dehydrogenase (Quinone) / metabolism*
  • Oxidoreductases / metabolism*
  • Parkinson Disease / blood
  • Parkinson Disease / enzymology*
  • Reference Values
  • Succinate Dehydrogenase / metabolism*
  • Ubiquinone / analogs & derivatives*
  • Ubiquinone / metabolism


  • Coenzymes
  • Multienzyme Complexes
  • Ubiquinone
  • Oxidoreductases
  • Electron Transport Complex II
  • Succinate Dehydrogenase
  • NAD(P)H Dehydrogenase (Quinone)
  • Electron Transport Complex III
  • coenzyme Q10