Lupus anticoagulants: strong association with the major histocompatibility complex class II and platelet antibodies

Br J Haematol. 1997 Aug;98(2):342-5. doi: 10.1046/j.1365-2141.1997.2103027.x.


A relationship between the presence of platelet autoantibodies and major histocompatibilty complex class II alleles was determined in 27 patients with lupus anticoagulants. Twenty-two patients had a primary antiphospholipid syndrome' and five patients had lupus erythematosus (SLE). Platelet antibodies against the platelet glycoproteins (GP) IIb/IIIa were detectable in 20 patients. Anti-GPIb/IX or -GPIV antibodies were detectable only in patients with anti-GPIIb/IIIa antibodies. An increased frequency of HLA-DQB1*06 was demonstrable in the total patient population. The association between the lupus anticoagulants and HLA-DQB1*06 was even stronger if patients also had detectable platelet antibodies. This association was also seen if patients with a history of thromboembolic disease were considered separately. However, within the patient population there was no difference between frequencies of HLA alleles detectable platelet antibodies.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adolescent
  • Adult
  • Aged
  • Aged, 80 and over
  • Antibodies / analysis*
  • Antibodies, Anticardiolipin / analysis
  • Antiphospholipid Syndrome / immunology*
  • Blood Platelets / immunology*
  • Female
  • Genes, MHC Class II / immunology*
  • Histocompatibility Testing
  • Humans
  • Lupus Erythematosus, Systemic / immunology*
  • Male
  • Middle Aged
  • Platelet Glycoprotein GPIIb-IIIa Complex / immunology


  • Antibodies
  • Antibodies, Anticardiolipin
  • Platelet Glycoprotein GPIIb-IIIa Complex