CD3+ CD8+ CD56- clonal large granular lymphocyte leukaemia and HIV infection

Br J Haematol. 1997 Aug;98(2):444-5. doi: 10.1046/j.1365-2141.1997.1913009.x.


High-grade malignant lymphomas associated with HIV infection are usually derived from B lymphocytes. Although a broad spectrum of T-cell-derived malignancies has been described, no case of monoclonal T large granular lymphocyte leukaemia has been reported to date. We report a case of clonal T-LGL (CD3+, CD4-, CD8+, CD56-, CD57+) in an HIV-infected. HTLV1/2-negative individual. Large granular lymphocytes are thought to represent activated cytotoxic T lymphocytes. HIV infection, as previously reported for HTLV1/2, may represent a pathway of antigen activation and lead to clonal expansion of T large granular lymphocytes.

Publication types

  • Case Reports

MeSH terms

  • Aged
  • CD3 Complex / analysis*
  • CD4 Antigens / analysis
  • CD56 Antigen / analysis*
  • CD57 Antigens / analysis
  • CD8 Antigens / analysis*
  • Clone Cells
  • HIV Infections / complications
  • HIV Infections / immunology*
  • Humans
  • Immunophenotyping
  • Leukemia, Lymphoid / complications
  • Leukemia, Lymphoid / immunology*
  • Male


  • CD3 Complex
  • CD4 Antigens
  • CD56 Antigen
  • CD57 Antigens
  • CD8 Antigens