Changing indications for penetrating keratoplasty: a newly developed country's experience

Aust N Z J Ophthalmol. 1997 May;25(2):145-50. doi: 10.1111/j.1442-9071.1997.tb01296.x.


Purpose: To study the changing indications for penetrating keratoplasty in Singapore and compare local indications with developed countries with established corneal graft programs.

Methods: A descriptive study of all penetrating keratoplasty cases performed in the Singapore National Eye Center over a 5 year period, from 1 January 1991 to 31 December 1995 using records of the Singapore Eye Bank registry.

Results: A total of 327 penetrating keratoplasties were performed. Bullous keratopathy was the indication in more than a quarter of all cases (26.3%). Aphakic bullous keratopathy (11.6%) and pseudophakic bullous keratopathy (11.3%) accounted for the majority of the bullous keratopathy cases. The other leading indications were regrafts (11.9%), corneal dystrophies (10.4%), traumatic scarring (10.1%) and keratoconus (9.8%). A higher proportion of aphakic and pseudophakic bullous keratopathy as well as regrafts was noted in this series compared to a previous report on corneal transplantation in the 1980s. A rising indication rate of pseudophakic bullous keratopathy, in conjunction with a declining indication rate of herpetic keratitis was observed over the 5 year study period.

Conclusions: The indications for penetrating keratoplasty in Singapore appear to follow the trend seen in developed Western countries over the past few decades.

Publication types

  • Comparative Study

MeSH terms

  • Adolescent
  • Adult
  • Aged
  • Aged, 80 and over
  • Child
  • Child, Preschool
  • Cornea / surgery*
  • Corneal Diseases / surgery*
  • Female
  • Follow-Up Studies
  • Humans
  • Infant
  • Keratoplasty, Penetrating* / methods
  • Keratoplasty, Penetrating* / trends
  • Male
  • Middle Aged
  • Prospective Studies
  • Registries
  • Singapore
  • Treatment Outcome