Stage IV malignant intrapericardial germ cell tumor: a case report

Pediatr Hematol Oncol. 1997 Sep-Oct;14(5):451-5. doi: 10.3109/08880019709028775.


The mediastinum is a common site for germ cell tumors. We describe an unusual case in an 18-month-old girl who presented with respiratory distress and cardiomegaly. An echocardiogram revealed a large pericardial effusion and a mass adjacent to the heart. She underwent detailed investigation and at open exploration was found to have a wholly intrapericardial malignant yolk sac tumor. Staging investigations revealed a bony metastasis. The serum marker alpha-fetoprotein was elevated. She was treated with chemotherapy and is in remission 1 year after completion of treatment. We review the methods of diagnosis and follow-up of children with these tumors.

Publication types

  • Case Reports

MeSH terms

  • Antineoplastic Combined Chemotherapy Protocols / therapeutic use*
  • Female
  • Humans
  • Infant
  • Mediastinal Neoplasms* / diagnosis
  • Mediastinal Neoplasms* / drug therapy
  • Neoplasms, Germ Cell and Embryonal* / diagnosis
  • Neoplasms, Germ Cell and Embryonal* / drug therapy
  • Pericardial Effusion / pathology*
  • alpha-Fetoproteins / analysis


  • alpha-Fetoproteins