Induction of uncoupling protein-2 mRNA by troglitazone in the pancreatic islets of Zucker diabetic fatty rats

Biochem Biophys Res Commun. 1997 Aug 18;237(2):359-61. doi: 10.1006/bbrc.1997.7140.

Abstract

Because troglitazone, like leptin, lowers the triglyceride (TG) content of pancreatic islets, we searched for other leptinomimetic actions. Leptin upregulates the expression of uncoupling protein-2 (UCP-2) mRNA in islets of normal rats, but has no effect in islets of obese Zucker Diabetic Fatty (ZDF) rats with mutated leptin receptors. We report here that troglitazone also increases the UCP-2/beta-actin mRNA ratio by 115% in wild type ZDF rats and by 400% in obese ZDF rats.

Publication types

  • Research Support, U.S. Gov't, Non-P.H.S.
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Animals
  • Chromans / pharmacology*
  • Hypoglycemic Agents / pharmacology*
  • In Vitro Techniques
  • Ion Channels
  • Islets of Langerhans / drug effects*
  • Islets of Langerhans / metabolism
  • Male
  • Membrane Transport Proteins*
  • Mitochondrial Proteins*
  • Obesity / genetics*
  • Proteins / genetics*
  • RNA, Messenger / biosynthesis*
  • RNA, Messenger / genetics
  • Rats
  • Rats, Zucker
  • Thiazoles / pharmacology*
  • Thiazolidinediones*
  • Troglitazone
  • Uncoupling Protein 2
  • Up-Regulation / drug effects

Substances

  • Chromans
  • Hypoglycemic Agents
  • Ion Channels
  • Membrane Transport Proteins
  • Mitochondrial Proteins
  • Proteins
  • RNA, Messenger
  • Thiazoles
  • Thiazolidinediones
  • Ucp2 protein, rat
  • Uncoupling Protein 2
  • Troglitazone