[Results of two double-blind studies on the effect of silymarine in chronic hepatitis (author's transl)]

Leber Magen Darm. 1977 Oct;7(5):318-23.
[Article in German]


In two double-blind studies with 24 and 12 patients, respectively, the effect of silymarine on chronic hepatitis was studied. The treatment lasted three months to one year. In the laboratory tests investigated no remarkable difference between silymarine and placebo therapy was seen. Some histological changes, however, were improved under silymarine, one of them significantly. A control of these findings will be necessary. The question arises if silymarine occupies receptors on the liver cell membrane and therefore causes a partial blocking of immunologic reactions. The difficulties of prospective studies in chronic liver disease are emphasized.

Publication types

  • Clinical Trial
  • Controlled Clinical Trial
  • English Abstract

MeSH terms

  • Animals
  • Antibody Formation / drug effects
  • Cell Membrane / drug effects
  • Chronic Disease
  • Double-Blind Method
  • Drug Evaluation
  • Flavonoids / therapeutic use*
  • Hepatitis / drug therapy*
  • Hepatitis / immunology
  • Humans
  • Placebos
  • Silymarin / adverse effects
  • Silymarin / therapeutic use*


  • Flavonoids
  • Placebos
  • Silymarin