Review
doi: 10.1016/s0968-0004(97)01085-2.
Caspases: killer proteases
Affiliations
- PMID: 9270303
- DOI: 10.1016/s0968-0004(97)01085-2
Item in Clipboard
Review
Caspases: killer proteases
Trends Biochem Sci.
1997 Aug.
Abstract
Caspases (cysteinyl aspartate-specific proteinases) mediate highly specific proteolytic cleavage events in dying cells, which collectively manifest the apoptotic phenotype. The key and central role that these enzymes play in a biochemical cell-suicide pathway has been conserved throughout the evolution of multicellular eukaryotes.
Similar articles
-
The Caenorhabditis elegans cell-death protein CED-3 is a cysteine protease with substrate specificities similar to those of the human CPP32 protease.Genes Dev. 1996 May 1;10(9):1073-83. doi: 10.1101/gad.10.9.1073. Genes Dev. 1996. PMID: 8654923
-
A combinatorial approach defines specificities of members of the caspase family and granzyme B. Functional relationships established for key mediators of apoptosis.J Biol Chem. 1997 Jul 18;272(29):17907-11. doi: 10.1074/jbc.272.29.17907. J Biol Chem. 1997. PMID: 9218414
-
Mammalian cell death proteases: a family of highly conserved aspartate specific cysteine proteases.J Cell Biochem. 1997 Jan;64(1):33-42. doi: 10.1002/(sici)1097-4644(199701)64:1<33::aid-jcb6>3.0.co;2-0. J Cell Biochem. 1997. PMID: 9015752 Review.
-
ICE-related proteases in apoptosis.Curr Opin Genet Dev. 1996 Feb;6(1):50-5. doi: 10.1016/s0959-437x(96)90010-6. Curr Opin Genet Dev. 1996. PMID: 8791488 Review.
-
The three-dimensional structure of apopain/CPP32, a key mediator of apoptosis.Nat Struct Biol. 1996 Jul;3(7):619-25. doi: 10.1038/nsb0796-619. Nat Struct Biol. 1996. PMID: 8673606
Cited by
-
Multi-omics analysis deciphers intercellular communication regulating oxidative stress to promote oral squamous cell carcinoma progression.NPJ Precis Oncol. 2024 Nov 21;8(1):272. doi: 10.1038/s41698-024-00764-x. NPJ Precis Oncol. 2024. PMID: 39572698 Free PMC article.
-
Mitophagy in Cell Death Regulation: Insights into Mechanisms and Disease Implications.Biomolecules. 2024 Oct 9;14(10):1270. doi: 10.3390/biom14101270. Biomolecules. 2024. PMID: 39456203 Free PMC article. Review.
-
Gene Expression Regulation and the Signal Transduction of Programmed Cell Death.Curr Issues Mol Biol. 2024 Sep 16;46(9):10264-10298. doi: 10.3390/cimb46090612. Curr Issues Mol Biol. 2024. PMID: 39329964 Free PMC article. Review.
-
The crucial roles and research advances of cGAS‑STING pathway in liver diseases.Ann Med. 2024 Dec;56(1):2394588. doi: 10.1080/07853890.2024.2394588. Epub 2024 Aug 25. Ann Med. 2024. PMID: 39183465 Free PMC article. Review.
-
Retinol Binding Protein 4 Serves as a Potential Tumor Biomarker and Promotes Malignant Behavior in Gastric Cancer.Cancer Manag Res. 2024 Jul 24;16:891-908. doi: 10.2147/CMAR.S480337. eCollection 2024. Cancer Manag Res. 2024. PMID: 39072342 Free PMC article.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Other Literature Sources
Molecular Biology Databases
