Distinct and specific functions of cGMP-dependent protein kinases

Trends Biochem Sci. 1997 Aug;22(8):307-12. doi: 10.1016/s0968-0004(97)01086-4.


cGMP-dependent protein kinases I and II conduct signals from widespread signaling systems. Whereas the type I kinase mediates numerous effects of natriuretic peptides and nitric oxide in cardiovascular cells, the type II kinase transduces signals from the Escherichia coli heat-stable enterotoxin, STa, and from the endogenous intestinal peptide, guanylin, stimulating Cl- conductance of the cystic fibrosis transmembrane conductance regulator (CFTR). Although the two kinases may be interchangeable for several functions, CFTR regulation specifically requires the type II kinase.

Publication types

  • Comparative Study
  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Amino Acid Sequence
  • Animals
  • Cyclic GMP / metabolism
  • Cyclic GMP-Dependent Protein Kinases / chemistry
  • Cyclic GMP-Dependent Protein Kinases / genetics
  • Cyclic GMP-Dependent Protein Kinases / physiology*
  • Gene Expression Regulation, Enzymologic
  • Humans
  • Signal Transduction*
  • Species Specificity


  • Cyclic GMP-Dependent Protein Kinases
  • Cyclic GMP