Abstract
In Drosophila, pattern formation at multiple stages of embryonic and imaginal development depends on the same intercellular signaling pathways. We have identified a novel gene, eyelid (eld), which is required for embryonic segmentation, development of the notum and wing margin, and photoreceptor differentiation. In these tissues, eld mutations have effects opposite to those caused by wingless (wg) mutations. eld encodes a widely expressed nuclear protein with a region homologous to a novel family of DNA-binding domains. Based on this homology and on the phenotypic analysis, we suggest that Eld could act as a transcription factor antagonistic to the Wg pathway.
Publication types
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Research Support, Non-U.S. Gov't
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Research Support, U.S. Gov't, P.H.S.
MeSH terms
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Amino Acid Sequence
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Animals
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Body Patterning / genetics
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Cell Differentiation
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Cloning, Molecular
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DNA-Binding Proteins / analysis
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DNA-Binding Proteins / genetics*
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DNA-Binding Proteins / physiology
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Drosophila / embryology*
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Drosophila / genetics
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Drosophila / growth & development
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Drosophila Proteins*
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Gene Expression Regulation, Developmental
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Genes, Insect / genetics
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Molecular Sequence Data
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Mutation
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Phenotype
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Photoreceptor Cells, Invertebrate / chemistry
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Photoreceptor Cells, Invertebrate / cytology
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Photoreceptor Cells, Invertebrate / growth & development
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Proto-Oncogene Proteins / physiology*
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Recombinant Fusion Proteins
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Restriction Mapping
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Sequence Homology, Amino Acid
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Signal Transduction / physiology*
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Trans-Activators / genetics*
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Transcription Factors / analysis
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Transcription Factors / genetics*
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Transcription Factors / physiology
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Wings, Animal / growth & development
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Wnt1 Protein
Substances
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DNA-Binding Proteins
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Drosophila Proteins
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Proto-Oncogene Proteins
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Recombinant Fusion Proteins
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Trans-Activators
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Transcription Factors
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Wnt1 Protein
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osa protein, Drosophila
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wg protein, Drosophila