Sequence and expression of a novel member (LTBP-4) of the family of latent transforming growth factor-beta binding proteins

FEBS Lett. 1997 Jul 14;411(2-3):164-8. doi: 10.1016/s0014-5793(97)00685-6.


Overlapping cDNA clones from human heart and melanoma libraries were used to establish the 1587-residue sequence of a novel protein (LTBP-4) belonging to the family of extracellular microfibrillar proteins which also bind transforming growth factor-beta. LTBP-4 consists of 20 EG modules, 17 of them with a consensus sequence for calcium binding, 4 TB modules with 8 cysteines and several proline-rich regions. Northern blots demonstrated a single 5 kb mRNA which is highly expressed in heart but also present in skeletal muscle, pancreas, placenta and lung. The modular structure predicts that LTBP-4 should be a microfibrillar protein which probably also binds TGF-beta.

MeSH terms

  • Adaptor Proteins, Signal Transducing*
  • Amino Acid Sequence
  • Base Sequence
  • Blotting, Northern
  • Calcium / metabolism
  • Carrier Proteins / chemistry*
  • Carrier Proteins / genetics
  • Carrier Proteins / metabolism
  • Cloning, Molecular
  • Extracellular Matrix / chemistry
  • Gene Expression
  • Humans
  • Intracellular Signaling Peptides and Proteins*
  • Latent TGF-beta Binding Proteins
  • Melanoma / chemistry
  • Molecular Sequence Data
  • Muscle Proteins / chemistry*
  • Myocardium / chemistry
  • Protein Binding
  • RNA, Messenger / genetics
  • RNA, Messenger / metabolism
  • Sequence Alignment
  • Sequence Analysis, DNA
  • Transforming Growth Factor beta / metabolism


  • Adaptor Proteins, Signal Transducing
  • Carrier Proteins
  • Intracellular Signaling Peptides and Proteins
  • LTBP4 protein, human
  • Latent TGF-beta Binding Proteins
  • Muscle Proteins
  • RNA, Messenger
  • Transforming Growth Factor beta
  • Calcium

Associated data

  • GENBANK/Y13622