BIT, an immune antigen receptor-like molecule in the brain

FEBS Lett. 1997 Jul 14;411(2-3):327-34. doi: 10.1016/s0014-5793(97)00724-2.


We previously found a brain-specific glycoprotein in the rat brain. It postnatally increases and is rich in the mature brain. We cloned cDNA of this protein. It is composed of a signal peptide, a V-type immunoglobulin domain, two C1-type immunoglobulin domains, a transmembrane segment and a cytoplasmic region containing two tyrosine-based activation motifs (TAM) that are variants of the antigen receptor signaling motifs. The overall structure is similar to those of immune antigen receptors. This molecule, BIT (brain immunoglobulin-like molecule with TAMs), is a major endogenous substrates of brain tyrosine kinases in vitro. Cerebral cortical neurons could extend their neurites on BIT-coated substrate and anti-BIT monoclonal antibody specifically inhibited the effect. These findings and our recent study concerning BIT signal transduction mechanism suggest that BIT, an immune antigen receptor-like molecule of the brain, functions as a membrane signaling molecule that may participate in cell-cell interaction.

MeSH terms

  • Amino Acid Sequence
  • Animals
  • Antibodies, Monoclonal
  • Antigens, Differentiation*
  • Base Sequence
  • Blotting, Northern
  • Brain / cytology
  • Brain / immunology
  • Brain / metabolism*
  • Cells, Cultured
  • Cloning, Molecular
  • Immunoblotting
  • Laminin / metabolism
  • Membrane Glycoproteins*
  • Molecular Sequence Data
  • Nerve Tissue Proteins / chemistry
  • Nerve Tissue Proteins / physiology*
  • Neural Cell Adhesion Molecule L1*
  • Neurites / ultrastructure
  • Neurons / cytology
  • Phosphotyrosine / metabolism
  • Protein-Tyrosine Kinases / metabolism
  • RNA, Messenger / analysis
  • Rats
  • Receptors, Immunologic / chemistry
  • Receptors, Immunologic / physiology*
  • Sequence Alignment
  • Signal Transduction / physiology


  • Antibodies, Monoclonal
  • Antigens, Differentiation
  • Laminin
  • Membrane Glycoproteins
  • Nerve Tissue Proteins
  • Neural Cell Adhesion Molecule L1
  • RNA, Messenger
  • Receptors, Immunologic
  • Phosphotyrosine
  • Protein-Tyrosine Kinases

Associated data

  • GENBANK/D38468