Is screening for thyroid carcinoma indicated in familial adenomatous polyposis? The Leeds Castle Polyposis Group

Int J Colorectal Dis. 1997;12(4):240-2. doi: 10.1007/s003840050097.


Forty-five polyposis patients with thyroid carcinoma constituted 1.2% of the patients in the Leeds Castle Polyposis Group database. The patients were diagnosed during 1959-1995; 44 were females at a median age of 25 years (range 10-40) and 37 (82%) had papillary carcinoma. At the end of 1995 only one patient (9%) had died from thyroid carcinoma, and the ten-year cumulative survival was 84% (95% confidence limits 72-97). Due to the low incidence of thyroid carcinoma in FAP and the good prognosis we do not recommend a regular thyroid screening in polyposis, as this is unlikely to result in a reduction of the mortality, but will only aggravate existing cancrophobia in these strained patients.

MeSH terms

  • Adenomatous Polyposis Coli / complications*
  • Adolescent
  • Adult
  • Carcinoma, Papillary / diagnosis*
  • Carcinoma, Papillary / etiology
  • Carcinoma, Papillary / mortality
  • Child
  • Female
  • Humans
  • Male
  • Prognosis
  • Survival Analysis
  • Thyroid Neoplasms / diagnosis*
  • Thyroid Neoplasms / etiology
  • Thyroid Neoplasms / mortality