Prognostic value of basic fibroblast growth factor and its receptor (FGFR-1) in patients with non-small cell lung carcinomas

Eur J Cancer. 1997 Apr;33(4):691-3. doi: 10.1016/s0959-8049(96)00411-x.

Abstract

Tumour specimens of 206 patients with untreated non-small cell lung carcinomas (NSCLC) were analysed immunohistochemically for the expression of the basic fibroblast growth factor (bFGF) and for its receptor (FGFR-1, Flg). Seventy of the tumours showed weak expression, 109 moderate and 27 high expression of bFGF. Thirty-eight tumours had low expression of FGFR-1, 116 had moderate and 52 cases high expression. Patients with high FGFR-1 expression had significantly shorter survival times than patients with weak or moderate expressions (P < 0.05), but there was no significant correlation between bFGF expression and patient survival. The results of the multivariate analysis demonstrated that FGFR-1 in the presence of stage is not an independent prognostic factor.

MeSH terms

  • Carcinoma, Non-Small-Cell Lung / chemistry*
  • Female
  • Fibroblast Growth Factor 2 / analysis*
  • Humans
  • Immunohistochemistry
  • Lung Neoplasms / chemistry*
  • Male
  • Middle Aged
  • Multivariate Analysis
  • Neoplasm Proteins / analysis*
  • Prognosis
  • Receptors, Fibroblast Growth Factor / analysis*

Substances

  • Neoplasm Proteins
  • Receptors, Fibroblast Growth Factor
  • Fibroblast Growth Factor 2