Prevention of parenteral nutrition-induced gut hypoplasia by coinfusion of glucagon-like peptide-2

Am J Physiol. 1997 Aug;273(2 Pt 1):G559-63. doi: 10.1152/ajpgi.1997.273.2.G559.


Maintaining rats on total parenteral nutrition (TPN) for 6 days significantly reduced mass (-34%), protein (-32%), and DNA (-35%) in small intestine and colon (29-37% decrease). Coinfusion of glucagon-like peptide-2 (GLP-2) normalized each of these variables in duodenum, jejunum, and ileum, but not in colon. Histological analysis of tissue revealed normal mucosa thickness and villus height in small intestine of GLP-2-treated rats, whereas nontreated rats maintained on TPN exhibited villus shortening (-30%) and thinning (-23%) of mucosa. These results suggest that hormonal alterations may be more important than an absence of luminal nutrition in TPN-associated mucosal changes. Additionally, GLP-2 normalization of gut mucosa permits accurate assessment of the influence of reversal of hypoplasia on gut barrier function.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, Non-P.H.S.

MeSH terms

  • Animals
  • DNA / metabolism
  • Glucagon-Like Peptide 2
  • Glucagon-Like Peptides
  • Intestinal Diseases / etiology*
  • Intestinal Diseases / prevention & control*
  • Intestinal Mucosa / pathology
  • Intestine, Small / metabolism
  • Intestine, Small / pathology
  • Male
  • Microvilli / pathology
  • Parenteral Nutrition / adverse effects*
  • Peptides / therapeutic use*
  • Rats
  • Rats, Inbred F344


  • Glucagon-Like Peptide 2
  • Peptides
  • Glucagon-Like Peptides
  • DNA