Skip to main page content
Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
, 277 (5331), 1453-62

The Complete Genome Sequence of Escherichia Coli K-12

Affiliations

The Complete Genome Sequence of Escherichia Coli K-12

F R Blattner et al. Science.

Abstract

The 4,639,221-base pair sequence of Escherichia coli K-12 is presented. Of 4288 protein-coding genes annotated, 38 percent have no attributed function. Comparison with five other sequenced microbes reveals ubiquitous as well as narrowly distributed gene families; many families of similar genes within E. coli are also evident. The largest family of paralogous proteins contains 80 ABC transporters. The genome as a whole is strikingly organized with respect to the local direction of replication; guanines, oligonucleotides possibly related to replication and recombination, and most genes are so oriented. The genome also contains insertion sequence (IS) elements, phage remnants, and many other patches of unusual composition indicating genome plasticity through horizontal transfer.

Comment in

Similar articles

See all similar articles

Cited by 2,405 PubMed Central articles

See all "Cited by" articles

Publication types

MeSH terms

Associated data

LinkOut - more resources

Feedback