Binding of neuroligins to PSD-95

Science. 1997 Sep 5;277(5331):1511-5. doi: 10.1126/science.277.5331.1511.

Abstract

PSD-95 is a component of postsynaptic densities in central synapses. It contains three PDZ domains that localize N-methyl-D-aspartate receptor subunit 2 (NMDA2 receptor) and K+ channels to synapses. In mouse forebrain, PSD-95 bound to the cytoplasmic COOH-termini of neuroligins, which are neuronal cell adhesion molecules that interact with beta-neurexins and form intercellular junctions. Neuroligins bind to the third PDZ domain of PSD-95, whereas NMDA2 receptors and K+ channels interact with the first and second PDZ domains. Thus different PDZ domains of PSD-95 are specialized for distinct functions. PSD-95 may recruit ion channels and neurotransmitter receptors to intercellular junctions formed between neurons by neuroligins and beta-neurexins.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Amino Acid Sequence
  • Animals
  • COS Cells
  • Calcium-Calmodulin-Dependent Protein Kinases*
  • Cell Adhesion Molecules, Neuronal
  • Cell Line
  • Cell Membrane / metabolism
  • Cytoplasm / metabolism
  • Disks Large Homolog 4 Protein
  • Guanylate Kinases
  • Intercellular Junctions / metabolism
  • Intracellular Signaling Peptides and Proteins
  • Membrane Proteins / chemistry
  • Membrane Proteins / metabolism*
  • Mice
  • Molecular Sequence Data
  • Nerve Tissue Proteins / chemistry
  • Nerve Tissue Proteins / metabolism*
  • Neurons / metabolism*
  • Nucleoside-Phosphate Kinase / metabolism
  • Potassium Channels / metabolism
  • Prosencephalon / metabolism*
  • Receptors, N-Methyl-D-Aspartate / metabolism
  • Recombinant Fusion Proteins / metabolism
  • Tumor Suppressor Proteins

Substances

  • Cell Adhesion Molecules, Neuronal
  • Disks Large Homolog 4 Protein
  • Dlg4 protein, mouse
  • Intracellular Signaling Peptides and Proteins
  • Membrane Proteins
  • Nerve Tissue Proteins
  • Potassium Channels
  • Receptors, N-Methyl-D-Aspartate
  • Recombinant Fusion Proteins
  • Tumor Suppressor Proteins
  • neuroligin 1
  • neuroligin 2
  • neuroligin 3
  • postsynaptic density proteins
  • neurexin Ibeta
  • CASK kinases
  • Calcium-Calmodulin-Dependent Protein Kinases
  • Nucleoside-Phosphate Kinase
  • DLG2 protein, human
  • Guanylate Kinases