Abstract
Silicon plays a physiologically essential but mechanistically obscure role in promoting the synthesis of mucopolysaccharides and collagen. In light of reports that increased silicon ingestion impedes cholesterol-induced atherogenesis in rabbits and may be associated epidemiologically with reduced cardiovascular risk, it is reasonable to speculate that supplemental silicon may stimulate endothelial production of heparan sulfate proteoglycans that inhibit intimal hyperplasia.
MeSH terms
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Animals
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Arteriosclerosis / epidemiology
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Arteriosclerosis / prevention & control*
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Cardiovascular Diseases / epidemiology
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Cardiovascular Diseases / prevention & control
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Cholesterol, Dietary
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Diet, Atherogenic
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Endothelium, Vascular / drug effects
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Endothelium, Vascular / metabolism*
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Heparan Sulfate Proteoglycans
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Heparitin Sulfate / biosynthesis*
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Humans
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Models, Cardiovascular
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Proteoglycans / biosynthesis*
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Rabbits
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Risk Factors
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Silicon / pharmacology*
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Silicon / therapeutic use
Substances
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Cholesterol, Dietary
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Heparan Sulfate Proteoglycans
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Proteoglycans
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Heparitin Sulfate
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Silicon