Lymphangiomas in children: percutaneous sclerotherapy with an alcoholic solution of zein

Radiology. 1997 Sep;204(3):651-4. doi: 10.1148/radiology.204.3.9280239.


Purpose: To determine the efficacy of percutaneous sclerotherapy with an alcoholic solution of zein in lymphangiomas in pediatric patients.

Materials and methods: Fourteen patients with macrocystic and mixed lymphangiomas were treated with use of Ethibloc as a sclerosing agent. The procedure was performed with ultrasonographic and/or fluoroscopic guidance. Follow-up clinical and sequential computed tomographic examinations were performed to evaluate regression of the lesion.

Results: Regression was excellent in nine (64%) of the 14 lesions: Regression was complete in four lymphangiomas and was to less than 5% of the initial volume in five. Satisfactory results were obtained in the remaining five (36%) of 14 lesions. The most frequent complication was leakage of Ethibloc without important sequelae in 10 of the 14 lymphangiomas.

Conclusion: Percutaneous sclerotherapy with Ethibloc was a safe and effective procedure in the treatment of macrocystic and mixed lymphangiomas.

MeSH terms

  • Adolescent
  • Axilla
  • Child
  • Child, Preschool
  • Diatrizoate / adverse effects
  • Diatrizoate / therapeutic use*
  • Drug Combinations
  • Fatty Acids / adverse effects
  • Fatty Acids / therapeutic use*
  • Female
  • Follow-Up Studies
  • Head and Neck Neoplasms / therapy*
  • Humans
  • Infant
  • Infant, Newborn
  • Lymphangioma / therapy*
  • Male
  • Propylene Glycols / adverse effects
  • Propylene Glycols / therapeutic use*
  • Prospective Studies
  • Radiography, Interventional
  • Sclerosing Solutions / adverse effects
  • Sclerosing Solutions / therapeutic use*
  • Sclerotherapy*
  • Ultrasonography, Interventional
  • Zein / adverse effects
  • Zein / therapeutic use*


  • Drug Combinations
  • Fatty Acids
  • Propylene Glycols
  • Sclerosing Solutions
  • Diatrizoate
  • Zein
  • alcoholic prolamine solution