Cholestyramine influences meal-stimulated pancreaticobiliary function and plasma cholecystokinin independent of gastric emptying and food digestion

Scand J Gastroenterol. 1997 Aug;32(8):778-84. doi: 10.3109/00365529708996534.

Abstract

Background: Cholestyramine enhances gallbladder emptying and plasma cholecystokinin responses to oral ingestion of a mixed meal. It is not known whether this effect occurs independently of alterations in gastric emptying or maldigestion of nutrients.

Methods: We perfused 15 g of an amino acid meal intraduodenally for 60 min in seven healthy volunteers, once with and once without cholestyramine. Intraduodenal perfusion of saline with or without cholestyramine (6 g/h) was started 60 min before the amino acid meal and continued for 2 h.

Results: Cholestyramine markedly enhanced the incremental plasma cholecystokinin response to the meal from 36 +/- 12 to 139 +/- 25 pmol/l x 60 min (P < 0.005), incremental amylase output from 2.4 +/- 0.7 to 5.7 +/- 0.7 kU/h (P < 0.05), and incremental integrated gallbladder contraction from 1948 +/- 235 to 2840 +/- 189% x 60 min (P < 0.05).

Conclusion: The enhancing effect of cholestyramine on postprandial gallbladder contraction, pancreatic enzyme secretion, and plasma cholecystokinin release is not dependent on gastric emptying rates or appropriate digestion of nutrients.

Publication types

  • Clinical Trial
  • Randomized Controlled Trial

MeSH terms

  • Adult
  • Amino Acids / administration & dosage
  • Amylases / drug effects*
  • Amylases / metabolism
  • Anticholesteremic Agents / administration & dosage*
  • Cholecystokinin / blood
  • Cholecystokinin / drug effects*
  • Cholestyramine Resin / administration & dosage*
  • Digestion / drug effects
  • Eating / physiology*
  • Female
  • Gallbladder Emptying / drug effects
  • Gastric Emptying / drug effects*
  • Humans
  • Male
  • Pancreatic Polypeptide / blood
  • Pancreatic Polypeptide / drug effects*
  • Radioimmunoassay
  • Reference Values
  • Sodium Chloride / administration & dosage

Substances

  • Amino Acids
  • Anticholesteremic Agents
  • Cholestyramine Resin
  • Sodium Chloride
  • Pancreatic Polypeptide
  • Cholecystokinin
  • Amylases