Focal inflammatory infiltrations in gastric biopsy specimens are suggestive of Crohn's disease. Crohn's Disease Study Group, Germany

Scand J Gastroenterol. 1997 Aug;32(8):813-8. doi: 10.3109/00365529708996539.


Background: Crohn's disease is a systemic inflammatory disease that may involve all regions of the gut.

Methods: Thirty-six patients with Crohn's disease and 36 age- and sex-matched control patients were prospectively evaluated by upper endoscopy. Biopsy specimens were taken from the oesophagus, duodenum, and 10 locations in the antrum and corpus.

Results: Granulomas were found in four patients (11.13%) with Crohn's disease but in none of the control patients (P > 0.5). In 23 of 36 patients (63.9%) with Crohn's disease focal inflammatory infiltrations were found, as compared with 7 of 36 (19.4%) of the controls (P < 0.001). For focal inflammatory infiltrations, an odds ratio of 7.33 (2.55-21.38) was calculated, which increased to 20.04 (4.07-98.45) when only specimens from the angulus were considered. Helicobacter pylori infection was present in 13 of 36 controls (36.1%) and in 3 of 36 patients (8.3%) with Crohn's disease (P = 0.009).

Conclusion: These data suggest that Crohn's disease is typically associated with focal inflammatory infiltrations of the gastric mucosa.

Publication types

  • Clinical Trial
  • Controlled Clinical Trial
  • Multicenter Study

MeSH terms

  • Adult
  • Biopsy
  • Chi-Square Distribution
  • Crohn Disease / pathology*
  • Diagnosis, Differential
  • Duodenum / pathology*
  • Endoscopy, Gastrointestinal
  • Esophagus / pathology*
  • Female
  • Gastric Mucosa / pathology*
  • Humans
  • Male
  • Middle Aged
  • Odds Ratio
  • Prospective Studies