Genetic factors in the development of atheroma and on serum total cholesterol levels in inbred mice and their hybrids

Prog Biochem Pharmacol. 1977;13:298-305.


There is a consistent genetic relationship between the development of atheromata in the aortic sinus wall and serum total cholesterol levels using inbred strains of male mice. This relationship is dependent on a multifactorial (polygenic) type of inheritance that is more complicated than the simple additive-dominance model. There is no special maternal or paternal influence on serum total cholesterol levels or on the development of atheromata.

MeSH terms

  • Animals
  • Arteries / pathology
  • Arteriosclerosis / genetics*
  • Arteriosclerosis / pathology
  • Cholesterol / blood*
  • Crosses, Genetic
  • Diet, Atherogenic
  • Female
  • Genes
  • Hypercholesterolemia / genetics*
  • Male
  • Mice
  • Mice, Inbred CBA
  • Mice, Inbred Strains*


  • Cholesterol