MCM4 and PRKDC, human genes encoding proteins MCM4 and DNA-PKcs, are close neighbours located on chromosome 8q12-->q13

Cytogenet Cell Genet. 1997;77(3-4):268-70. doi: 10.1159/000134594.

Abstract

A human genomic DNA fragment containing the 5' region of MCM4, a gene encoding replication protein MCM4/Cdc21 was isolated. At a distance of about 800 base pairs upstream of MCM4, the fragment was shown to also contain the 5' end of PRKDC, a gene encoding the catalytic subunit of the DNA-dependent protein kinase (DNA-PKcs). The genomic DNA fragment was used for hybridization to human metaphase chromosome spreads. The cytogenetic map location of the two closely adjacent genes was determined to be 8q12-->q13.

MeSH terms

  • Cell Cycle Proteins / genetics*
  • Chromosome Mapping
  • Chromosomes, Human, Pair 8 / genetics*
  • Chromosomes, Human, Pair 8 / ultrastructure
  • DNA Replication / genetics
  • DNA-Activated Protein Kinase
  • DNA-Binding Proteins*
  • Humans
  • In Situ Hybridization, Fluorescence
  • Minichromosome Maintenance Complex Component 4
  • Molecular Sequence Data
  • Nuclear Proteins
  • Protein-Serine-Threonine Kinases / genetics*
  • Restriction Mapping
  • Schizosaccharomyces pombe Proteins*

Substances

  • Cell Cycle Proteins
  • DNA-Binding Proteins
  • Nuclear Proteins
  • Schizosaccharomyces pombe Proteins
  • DNA-Activated Protein Kinase
  • PRKDC protein, human
  • Protein-Serine-Threonine Kinases
  • Minichromosome Maintenance Complex Component 4
  • mcm4 protein, S pombe

Associated data

  • GENBANK/U47077
  • GENBANK/U90415
  • GENBANK/X74794