Differential expression patterns of the PEA3 group transcription factors through murine embryonic development

Oncogene. 1997 Aug 18;15(8):937-52. doi: 10.1038/sj.onc.1201261.


ERM, ER81 and PEA3 are three highly related transcription factors belonging to the ETS family. Together they form the PEA3 group within this family. Little data is yet available regarding the roles of these three genes during embryonic development. A prerequisite to investigations in this field is to obtain an accurate spatio-temporal expression map for the erm, er81 and pea3 genes. To this end, we have used in situ hybridization to compare their expression patterns during critical stages of murine embryogenesis. We report that all three genes are expressed in numerous developing organs coming from different embryonic tissues. The three genes appeared co-expressed in different organs but presented specific sites of expression, so that the resultant expression pattern could in fact reveal several distinct functions depending upon isolated and/or various combinations of the PEA3 member expression. These results suggest that erm, er81 and pea3 genes are differentially regulated, probably to serve important functions as cell proliferation control, tissue interaction mediator or cell differentiation, all over successive steps of the mouse organogenesis.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Amino Acid Sequence
  • Animals
  • Base Sequence
  • Blotting, Northern
  • Central Nervous System / embryology
  • DNA, Complementary / isolation & purification
  • DNA-Binding Proteins / genetics
  • DNA-Binding Proteins / metabolism*
  • Ectoderm / metabolism
  • Embryo, Mammalian / metabolism*
  • Embryonic and Fetal Development
  • Endoderm / metabolism
  • Gene Expression
  • Mesoderm / metabolism
  • Mice
  • Molecular Sequence Data
  • Transcription Factors / genetics
  • Transcription Factors / metabolism*


  • DNA, Complementary
  • DNA-Binding Proteins
  • Etv1 protein, mouse
  • Etv5 protein, mouse
  • Transcription Factors
  • transcription factor PEA3