Regression of myopia induced by pregnancy after photorefractive keratectomy

J Refract Surg. 1997 Aug;13(5 Suppl):S445-6. doi: 10.3928/1081-597X-19970801-13.


Background: We evaluated refractive corneal changes that occurred in women who become pregnant after undergoing excimer laser photorefractive keratectomy (PRK) for the treatment of myopia.

Methods: Refractive results of 18 eyes of nine women who underwent PRK and became pregnant during the follow-up period were reviewed. All eyes were followed for a least 12 months after PRK. Subjective refraction, slit-lamp microscopy, and intraocular pressure were measured at each follow-up examination.

Results: Twelve of 18 eyes (66%) had myopic regression during the follow-up period. The regression was associated with 1+ to 2+ corneal haze in 10 of these 12 eyes (83.3%). The three women (6 eyes) who had stable refractions after PRK became pregnant at least 5 months postoperatively. The corneal haze and the associated myopic regression improved in 50% of the eyes after delivery.

Conclusion: Pregnancy seems to induce effects on corneal wound healing following PRK.

MeSH terms

  • Adult
  • Cornea / physiopathology*
  • Cornea / surgery
  • Female
  • Follow-Up Studies
  • Humans
  • Lasers, Excimer
  • Myopia / physiopathology*
  • Myopia / surgery
  • Photorefractive Keratectomy*
  • Pregnancy* / physiology
  • Refraction, Ocular
  • Visual Acuity
  • Wound Healing / physiology