The CD40-CD154 system in anti-infective host defense

Curr Opin Immunol. 1997 Aug;9(4):491-7. doi: 10.1016/s0952-7915(97)80100-8.


Research in the past few years has documented significant advances in our understanding of the CD40-CD40 ligand (CD154) system in diverse immune functions. This system influences many T cell mediated inflammatory immune responses and effector functions, unmasking a previously unexpected role for CD40-CD154 in cell mediated immunity. Manipulation of CD154 in animal models of infection by the use of CD154-deficient mice or anti-CD154 antibodies has shown the importance of this system in the initiation of the inflammatory response, in the activation of antigen-presenting cells and in resistance to infections.

Publication types

  • Review

MeSH terms

  • Animals
  • Antigen Presentation*
  • Borrelia Infections / immunology
  • CD40 Antigens / immunology*
  • CD40 Ligand
  • Humans
  • Infections / immunology*
  • Leishmaniasis / immunology
  • Listeriosis / immunology
  • Macrophage Activation
  • Membrane Glycoproteins / immunology*
  • Mice
  • Nematode Infections / immunology
  • Pneumocystis Infections / immunology
  • T-Lymphocyte Subsets / immunology*


  • CD40 Antigens
  • Membrane Glycoproteins
  • CD40 Ligand