Role of dendritic and follicular dendritic cells in HIV infection and pathogenesis

Curr Opin Immunol. 1997 Aug;9(4):563-7. doi: 10.1016/s0952-7915(97)80111-2.

Abstract

Dendritic cells (DCs) and follicular dendritic cells (FDCs) play important roles in HIV-mediated pathogenesis. Recent studies have defined new DC subsets and shown that DCs in lymphoid mucosa can both harbor virus and stimulate its spread into CD4(+) T cells. FDCs harbor unspliced HIV mRNA and immune complexed virus, but not actively infectious virus, yet these cells are a key regulated reservoir of virions.

Publication types

  • Research Support, U.S. Gov't, P.H.S.
  • Review

MeSH terms

  • Antigen Presentation
  • Dendritic Cells / immunology*
  • Dendritic Cells / virology
  • HIV / physiology*
  • HIV Antigens / immunology
  • HIV Infections / etiology
  • HIV Infections / immunology*
  • Humans
  • Lymph Nodes / immunology
  • Lymph Nodes / ultrastructure
  • Mucous Membrane / immunology
  • Mucous Membrane / pathology
  • RNA, Messenger / metabolism
  • RNA, Viral / metabolism
  • Receptors, Virus / physiology
  • Virion / physiology
  • Virus Replication

Substances

  • HIV Antigens
  • RNA, Messenger
  • RNA, Viral
  • Receptors, Virus