Activation and inactivation steps in the visual transduction pathway

Curr Opin Neurobiol. 1997 Aug;7(4):500-4. doi: 10.1016/s0959-4388(97)80029-3.


Recent genetic, biochemical and electrophysiological evidence has provided insights into the molecular identity of the substance responsible for bleaching desensitization in vision. Studies examining the molecular defects that cause delayed dark adaptation suggest that the desensitizing substance is recognized by rhodopsin kinase and/or arrestin and, therefore, is probably a complex comprising all-trans-retinal and opsin.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.
  • Review

MeSH terms

  • Animals
  • Electrophysiology
  • Humans
  • Rhodopsin / physiology
  • Signal Transduction / physiology*
  • Visual Pathways / physiology*


  • Rhodopsin