Guidelines are suggested for European curricula in Health Informatics that apply to both healthcare professionals and health administrative staff. These guidelines are the results of in-depth discussions and thoughts of the EU-EDUCTRA concerted action. Emphasis is placed on the way information is generated in the health domain. The guidelines also consider the various actors, their position and role in the healthcare structure. Characteristics of and operations on health information are discussed. Data quality control, ethical issues, benefits and potential caveats related to health information are also outlined. The article concludes with a list of possible applications.