Abstract
Extracts of involved and uninvolved skin from nine patients with untreated psoriasis were studied for chemotactic activity. Psoriatic plaque contains increased amounts of a complement-dependent chemotactic factor that is inhibited by diisopropyl fluorophosphate. This factor may be human skin serine proteinase.
Publication types
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Research Support, U.S. Gov't, P.H.S.
MeSH terms
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Animals
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Biological Assay
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Chemotaxis, Leukocyte* / drug effects
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Complement System Proteins / metabolism*
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Humans
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Isoflurophate / pharmacology
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Mice
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Neutrophils / immunology*
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Peptide Hydrolases / metabolism
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Protease Inhibitors
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Psoriasis / enzymology
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Psoriasis / immunology*
Substances
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Protease Inhibitors
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Isoflurophate
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Complement System Proteins
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Peptide Hydrolases