Abstract
Chronic treatment with Withania somnifera (Ws) (family: Solanaceae, 100 mg/kg) commercial root extract followed by saline on days 1-9 failed to produce any significant change in tailflick latency from the saline pretreated group in mice. However, repeated administration of Ws (100 mg/kg) for 9 days attenuated the development of tolerance to the analgesic effect of morphine (10 mg/kg). Ws (100 mg/kg) also suppressed morphine-withdrawal jumps, a sign of the development of dependence to opiate as assessed by naloxone (2 mg/kg) precipitation withdrawal on day 10 of testing.
MeSH terms
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Administration, Oral
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Animals
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Disease Models, Animal
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Dose-Response Relationship, Drug
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Drug Tolerance
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Female
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Injections, Subcutaneous
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Male
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Mice
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Morphine / administration & dosage
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Morphine / toxicity*
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Morphine Dependence / drug therapy*
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Naloxone / administration & dosage
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Naloxone / therapeutic use
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Narcotic Antagonists / administration & dosage
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Narcotic Antagonists / therapeutic use*
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Narcotics / administration & dosage
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Narcotics / toxicity*
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Plant Extracts / administration & dosage
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Plant Extracts / therapeutic use*
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Plant Roots / metabolism
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Saline Solution, Hypertonic / administration & dosage
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Substance Withdrawal Syndrome / drug therapy*
Substances
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Narcotic Antagonists
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Narcotics
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Plant Extracts
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Saline Solution, Hypertonic
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Naloxone
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Morphine