Association between nonadministration of subconjunctival cefuroxime and postoperative endophthalmitis

J Cataract Refract Surg. Jul-Aug 1997;23(6):889-93. doi: 10.1016/s0886-3350(97)80249-0.

Abstract

Purpose: To determine whether not administering subconjunctival cefuroxime during cataract surgery is associated with postoperative endophthalmitis.

Setting: Southampton Eye Unit, Southampton General Hospital, England.

Methods: This retrospective, case-control study comprised nine patients who developed endophthalmitis after cataract surgery in a single ophthalmic unit over a 21 month period. Ten control patients for each case were randomly chosen from patients having cataract surgery within 1 week of the endophthalmitis case.

Results: None of the nine endophthalmitis patients received peroperative subconjunctival cefuroxime compared with 43 of 90 control patients (47.8%) (P = 0.008). No other variables were found to be associated with development of endophthalmitis in this study.

Conclusion: Nonadministration of subconjunctival cefuroxime was associated with subsequent endophthalmitis. A further study to determine whether the observed association is causal is therefore warranted.

Publication types

  • Clinical Trial
  • Randomized Controlled Trial
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Aged
  • Aged, 80 and over
  • Anterior Chamber / microbiology
  • Antibiotic Prophylaxis
  • Case-Control Studies
  • Cataract Extraction / adverse effects*
  • Cefuroxime / administration & dosage*
  • Cefuroxime / therapeutic use
  • Cephalosporins / administration & dosage*
  • Cephalosporins / therapeutic use
  • Conjunctiva
  • Endophthalmitis / microbiology
  • Endophthalmitis / prevention & control*
  • Eye Infections, Bacterial / etiology
  • Eye Infections, Bacterial / prevention & control*
  • Female
  • Humans
  • Male
  • Middle Aged
  • Retrospective Studies
  • Staphylococcal Infections / microbiology
  • Staphylococcal Infections / prevention & control*
  • Staphylococcus aureus / isolation & purification
  • Vitreous Body / microbiology

Substances

  • Cephalosporins
  • Cefuroxime