Farnesyltransferase inhibitors and cancer treatment: targeting simply Ras?

Biochim Biophys Acta. 1997 Aug 8;1333(1):F51-71. doi: 10.1016/s0304-419x(97)00011-5.
No abstract available

Publication types

  • Research Support, U.S. Gov't, P.H.S.
  • Review

MeSH terms

  • Alkyl and Aryl Transferases*
  • Animals
  • Antineoplastic Agents / pharmacology*
  • Cell Cycle
  • Cell Line / drug effects
  • Cell Line, Transformed / drug effects
  • Chemotherapy, Adjuvant
  • Drug Design
  • Farnesyltranstransferase
  • Genes, ras*
  • Humans
  • Mutation
  • Neoplasms / drug therapy
  • Neoplasms / enzymology
  • Neoplasms / genetics*
  • Protein Prenylation / drug effects
  • Transferases / antagonists & inhibitors*
  • ras Proteins / antagonists & inhibitors*
  • ras Proteins / genetics
  • ras Proteins / physiology

Substances

  • Antineoplastic Agents
  • Transferases
  • Alkyl and Aryl Transferases
  • Farnesyltranstransferase
  • ras Proteins