Calx, a Na-Ca exchanger gene of Drosophila melanogaster

Proc Natl Acad Sci U S A. 1997 Sep 16;94(19):10249-54. doi: 10.1073/pnas.94.19.10249.


We have cloned Calx, a gene that encodes a Na-Ca exchanger of Drosophila melanogaster. Calx encodes two repeated motifs, Calx-alpha and Calx-beta, that overlap domains required for exchanger activity and regulation. Calx has multiple transcripts in adults, including at least one expressed in the retina. The Calx genomic locus comprises >/=35 kb between the Atpalpha and rudimentary-like genes in chromosomal region 93B. In Xenopus oocytes, microinjected Calx cRNA induces calcium uptake like that of its homolog, the 3Na+-1Ca2+ exchanger of mammalian heart. Implications of Calx-alpha motifs for the mechanism of Na-Ca exchange are discussed.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, Non-P.H.S.
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Amino Acid Sequence
  • Animals
  • Antiporters*
  • Carrier Proteins / chemistry
  • Carrier Proteins / genetics*
  • Carrier Proteins / metabolism
  • Cloning, Molecular
  • DNA, Complementary
  • Drosophila Proteins*
  • Drosophila melanogaster / genetics*
  • Molecular Sequence Data
  • Sequence Homology, Amino Acid


  • Antiporters
  • Calx protein, Drosophila
  • Carrier Proteins
  • DNA, Complementary
  • Drosophila Proteins

Associated data

  • GENBANK/AF009897