Laser-induced thermal lesions in the human brain: short- and long-term appearance on MRI

J Comput Assist Tomogr. Sep-Oct 1997;21(5):818-25. doi: 10.1097/00004728-199709000-00031.


Purpose: The purpose of our study was to investigate with MRI the development of thermal lesions in the human brain up to almost 4 years after laser-induced interstitial thermotherapy (LITT).

Method: Eighteen patients with brain tumors who underwent LITT entered the study.

Results: In all patients the acute lesion comprised five concentric zones that showed reverse signal intensities on T1- versus T2-weighted images. Lesion development over time was uniform in 89% of the lesions. In two cases variations were observed.

Conclusion: The results of our MR follow-up studies showed that post-LITT, laser-induced lesions will shrink exponentially after an initial expansion without any pseudocystic effects.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Aged
  • Astrocytoma / therapy
  • Brain / pathology*
  • Brain Edema / pathology
  • Brain Neoplasms / therapy*
  • Contrast Media
  • Female
  • Follow-Up Studies
  • Gadolinium
  • Gadolinium DTPA
  • Glioma / therapy
  • Humans
  • Hyperthermia, Induced / methods*
  • Image Enhancement
  • Image Processing, Computer-Assisted
  • Laser Coagulation
  • Laser Therapy*
  • Longitudinal Studies
  • Magnetic Resonance Imaging*
  • Male
  • Middle Aged
  • Organometallic Compounds
  • Pentetic Acid / analogs & derivatives
  • Stereotaxic Techniques
  • Wound Healing


  • Contrast Media
  • Organometallic Compounds
  • Pentetic Acid
  • Gadolinium
  • Gadolinium DTPA