How Salmonella became a pathogen

Trends Microbiol. 1997 Sep;5(9):343-9. doi: 10.1016/S0966-842X(97)01099-8.


In many pathogens, virulence can be conferred by a single region of the genome. In contrast, the facultative intracellular lifestyle of Salmonella demands a large number of genes distributed around the chromosome. The evolution of Salmonella has been marked by the acquisition of several 'pathogenicity islands', each contributing to the unique virulence properties of this microorganism.

Publication types

  • Research Support, U.S. Gov't, Non-P.H.S.
  • Research Support, U.S. Gov't, P.H.S.
  • Review

MeSH terms

  • Chromosome Mapping
  • Gene Expression Regulation, Bacterial
  • Genes, Bacterial / physiology*
  • Gram-Negative Bacteria / genetics
  • Host-Parasite Interactions / physiology
  • Phylogeny
  • Salmonella / genetics
  • Salmonella / pathogenicity*
  • Salmonella / ultrastructure
  • Virulence / genetics*